ABSTRACT
<p><b>Objective</b>To investigate the relationship between seminal plasma zinc alpha-2 glycoprotein (ZAG) and semen quality in obese males.</p><p><b>METHODS</b>This study included 130 obese male patients with idiopathic infertility Based on the concentration of seminal plasma ZAG, we divided the patients into three tertile groups: tertile 1 (T1, 73.45－97.15 μg/ml, n = 43), T2 (97.16－115.46 μg/ml, n = 44), and T3 (115.47－220.11 μg/ml, n = 43). We measured the concentrations of seminal plasma zinc (SPZ) and ZAG of the patients by ELISA, obtained the semen parameters, and analyzed the correlation of semen quality with the levels of SPZ and ZAG and the influence of obesity on SPZ, ZAG and semen quality.</p><p><b>RESULTS</b>The mean level of seminal plasma ZAG in the 130 obese male patients was (111.29 ± 26.50) μg/ml. There were statistically significant differences in sperm concentration and total sperm count among the three tertile groups (P < 0.05). The level of seminal plasma ZAG was correlated negatively with the body mass index (BMI), waist circumference (WC), sperm concentration and sperm count (P < 0.01), that of SPZ positively with BMI and WC (P < 0.05) but negatively with semen volume and the percentage of progressively motile sperm (P < 0.05). The level of serum ZAG, however, exhibited no correlation with SPZ, seminal plasma ZAG or semen quality. Obesity was found to be associated with significantly decreased concentration of seminal plasma ZAG and percentage of progressively motile sperm but remarkably increased level of SPZ (P < 0.05).</p><p><b>CONCLUSIONS</b>Obesity may induce the metabolic disorder of SPZ and ZAG, change the microenvironment of seminal plasma, and consequently affect semen quality.</p>
Subject(s)
Humans , Male , Body Mass Index , Infertility, Male , Metabolism , Obesity , Metabolism , Semen , Chemistry , Semen Analysis , Seminal Plasma Proteins , Sperm Count , Sperm Motility , Spermatozoa , Metabolism , Waist CircumferenceABSTRACT
Objective To investigate the influence of sperm morphology, sperm DNA fragmentation index and seminal plasma zinc on pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET).MethodsA total of 341 infertile couples underwent IVF-ET were selected from January 2016 to June 2016 in our hospital.Sperm morphology, sperm DNA fragmentation index and seminal plasma zinc level were compared according to pregnancy.ResultsIn 341 cases, 204 cases pregnancy and 137 cases of no pregnancy, with the pregnancy rate of 59.8%(204/341).Compared with the pregnancy group, the percentage of normal sperm percentage was low, the abnormal sperm index was higher in the non-pregnant group (P<0.05), the sperm DNA index was higher (P<0.05).The percentage of normal sperm, sperm DNA fragmentation index and seminal plasma zinc and pregnancy rate in sperm morphology were linear (P<0.05), And there was a negative correlation between abnormal sperm index and sperm DNA fragment index (P<0.05), and other indicators were positively correlated (P<0.05).ConclusionSperm morphology, sperm DNA fragmentation index and seminal plasma zinc levels may influence the outcome of IVF-ET.The above parameters can be used to predict pregnancy outcome of IVF-ET.
ABSTRACT
Objective:To study the clinical effect of Bailing capsules in the treatment of diabetic impotence. Methods: Totally 136 cases of diabetic impotence were randomly divided into the observation group and the control group with 68 cases each. The obser-vation group was treated with Bailing capsules and the control group was with tadalafil tablets. The effect of the two groups was com-pared, and the changes in IIEF-5 score, serum testosterone ( T) and zinc ( Zn2+) before and after the treatment were studied as well. Results:The total effective rate of the observation group was 83. 82% while that of the control group was 67. 65%, and the difference was statistically significant (P0. 05), while IIEF-5 score was increased significantly (P0.05), while the serum testosterone (T) and IIEF-5 score were increased significantly in the observation group (P <0. 05). After the treatment, the symptoms in the two groups were both improved with increased IIEF-5 score, T and Zn2+, and the ob-servation group was with more obvious improvement. Conclusion:The effect of Bailing capsules in the treatment of diabetic impotence is promising, which is worthy of further study.